研究開発におけるマルチフィジックスシミュレーションの具体例

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COMSOL コンファレンス 2020 論文集を見る

Bioscience and Bioengineeringx

Optimisation of Sensor Integration in Organ-on-Chip Platforms

Jerome Charmet1, Samuel Wenger1, Adel Tekari1, Saskia Schmidt2, Loïc Burr3, Laura Suter-Dick2, Alexandra Kaempfer-Homsy1
1Haute Ecole Arc Ingénierie, HES-SO University of Applied Sciences Western Switzerland, 2000 Neuchâtel, Switzerland
2School of Life Sciences FHNW, Institute for Chemistry and Bioanalytics, Hofackerstrasse 30, 4132 Muttenz, Switzerland
3CSEM, Bahnhofstrasse 1, 7302 Landquart, Switzerland

Organs-on-Chips (OoCs) are microfluidics-based systems that aim to recapitulate the in-vivo behaviour of specific organs. Using a network of microfluidic channels, OoCs provide a biophysical and biochemical environment to sustain complex 2D and 3D cell cultures systems that recapitulate ... 詳細を見る

Optimization of the Oxygen Supply in Dynamic Cell Cultures

P. Elter1, E. Landrock-Bill1, C. Moseke1
1University of Applied Sciences Mittelhessen, Gießen, Germany

In many medical and biotechnological applications, cells are grown in dynamic cell cultures. Usually, the cells are cultivated on a scaffold with a complex channel structure through which the nutrient fluid flows and into which the cells can grow. However, a known problem is that the ... 詳細を見る

Optimizing Dielectrophoresis by Inducing Fluid Flow Using Droplet Oscillation

Marten Musiol1, Fenja Schröder1, Annalena Eckert1, Hans-Hermann Johannes1, Dieter Jahn2, Wolfgang Kowalsky1
1Institut für Hochfrequenztechnik, Technische Universität Braunschweig, Braunschweig, 38106, Germany
2Institute of Microbiology, Technische Universität Braunschweig, Braunschweig, 38106, Germany

In regular biosensors, the detected bacteria have to be in drawn towards the sensing area. To increase the sensitivity of the biosensors, bacteria should be drawn towards the sensing area, which can be achieved by dielectrophoresis (DEP). DEP is a mechanism which is used to move ... 詳細を見る

Simulation of Bioreactor Flow Characteristics and Cell Cultivation

Amer Alameri1
1Technische Hochschule Mittelhessen, IBMT - Institute for Biomedical Engineering

Bioreactors play a critical role in cultivating biological cells for various applications, such as pharmaceutical production and tissue engineering. Optimizing the cultivation process requires a deep understanding of the flow characteristics within the bioreactor medium. In this study, ... 詳細を見る

Analysis of cancer cell behaviour using sub-THz excitation in COMSOL Multiphysics

Monodipa Sarkar (2)1, Aayushi Sinha (1)2, Niraj Kumar (3)3
1Vacuum Electron Devices Design Group, Academy of Innovative and Scientific Research (AcSIR), Ghaziabad, India,2001002
2 Amity Institute of Biotechnology (Autonomous) , Amity University Noida, India, 201303
3Vacuum Electron Devices Design Group(CSIR-CEERI, Pilani) , Academy of Innovation and Scientific Research (AcSIR) Ghaziabad, India,2001002

In this paper, analysis of cancer cell using Sub-THz technology have been studied. Sub-THz technique for cancer detection is a much reliable and safer technique as compared to conventional methods [1,2]. To study the behavior of cancer cells and normal cells using Sub-THz technology, a ... 詳細を見る

Designing and Fabrication of Lab On a Chip for the Therapeutic Drug Monitoring of Erlotinib

Vivina Puthur 1, Sreema M.1, Jiya K. J.1, Ripsymol Toby1, Athira C.S.1, Arun Warrier1, Pooja Das M.1, Dr. Dhanya Gangadharan1, Dr. Jeethu Raveendran2
1Department of Biotechnology, Sahrdaya College of Engineering and Technology
2Department of Biomedical Engineering, Sahrdaya College of Engineering and Technology

Microfluidics and Biosensors are two principal fields that paved the way for the inception of Lab-on-a-chip (LOC) which provides early and cost-effective disease detection, from monitoring to treatment. LOC is a device that uses very small amounts of fluid on a microchip to do certain ... 詳細を見る

Geometry Optimization of Enzymatic Electrochemical Glucose Sensor

Nachiket Aashish Gokhale1, Kartik Jain1, Siddhartha Panda1
1Indian Institute of Technology Kanpur

Diabetes is a metabolic disorder that is on a rising tide. Diabetic patients must regularly monitor their blood glucose levels. One method for designing such a device is using electrochemical principles, specifically amperometry to determine glucose concentration. It is essential to ... 詳細を見る

Chemical Gradients, Carryover and Mixing in Fluidic Diagnostic Systems

Matthew Hancock1, Andrew Spann1, Andrew Fiore1
1Veryst Engineering, Needham, MA, United States

Recent events underscore the importance of rapid diagnostic tests for detecting viruses such as the SARS-CoV-2 coronavirus or for screening cancer biomarkers. Many fluidic-based diagnostics applications require careful control of chemical and biological species concentrations. In this ... 詳細を見る

Image based, geometry prescribed CFD of intra-cardiac flows on a dynamic heart phantom

Rasmus Hvid1, Marie Sand Traberg1
1Technical University of Denmark, department of health technology, Lyngby, Denmark

Introduction: The current gold standard for measuring intra-cardiac blood flow is cardiac magnetic resonance (CMR) and Color-Doppler ultrasound [ref1]. The presented simulation pipeline extracts heart wall motion from medical imaging and simulates the intra-cardiac blood flow as an ... 詳細を見る

FE-Simulation of PTCA Balloon Catheters

Cornelia Amstutz1, Roman Bühler1, Jean-Marc Behr2, Michael Stöver2, Adrian Zurbuchen1, Jürgen Burger2
1SITEM Center, University of Bern, Switzerland
2SIS Medical AG, Switzerland

Within 40 years, percutaneous transluminal coronary angioplasty (PTCA) catheters evolved into the golden standard for treating coronary stenoses. However, navigating through tortuous vessel pathways and cracking highly calcified lesions is challenging. To minimize the risk of ... 詳細を見る