研究開発におけるマルチフィジックスシミュレーションの具体例

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COMSOL コンファレンス 2020 論文集を見る

Bioscience and Bioengineeringx

Ionic Neuromodulation and Neurosensing Platform for In Vitro Studies

Jacopo Nicolini1, Federico Leva1, Claudio Verardo2, Pierpaolo Palestri3, Luca Selmi1
1Unimore - Università degli studi di Modena e Reggio Emilia
2Scuola Superiore Sant'Anna
3Università degli studi di Udine

Overview We successfully simulated a template iontronic system for closed-loop neuromodulation and neurosensing. The model’s goal is to support the careful design of novel platforms for in-vitro micro-electrode-array sensors coupled to conductive polymer-based (CP) ionic actuators used ... 詳細を見る

Optimizing Dielectrophoresis by Inducing Fluid Flow Using Droplet Oscillation

Marten Musiol1, Fenja Schröder1, Annalena Eckert1, Hans-Hermann Johannes1, Dieter Jahn2, Wolfgang Kowalsky1
1Institut für Hochfrequenztechnik, Technische Universität Braunschweig, Braunschweig, 38106, Germany
2Institute of Microbiology, Technische Universität Braunschweig, Braunschweig, 38106, Germany

In regular biosensors, the detected bacteria have to be in drawn towards the sensing area. To increase the sensitivity of the biosensors, bacteria should be drawn towards the sensing area, which can be achieved by dielectrophoresis (DEP). DEP is a mechanism which is used to move ... 詳細を見る

Optimization of the Oxygen Supply in Dynamic Cell Cultures

P. Elter1, E. Landrock-Bill1, C. Moseke1
1University of Applied Sciences Mittelhessen, Gießen, Germany

In many medical and biotechnological applications, cells are grown in dynamic cell cultures. Usually, the cells are cultivated on a scaffold with a complex channel structure through which the nutrient fluid flows and into which the cells can grow. However, a known problem is that the ... 詳細を見る

Optimisation of Sensor Integration in Organ-on-Chip Platforms

Jerome Charmet1, Samuel Wenger1, Adel Tekari1, Saskia Schmidt2, Loïc Burr3, Laura Suter-Dick2, Alexandra Kaempfer-Homsy1
1Haute Ecole Arc Ingénierie, HES-SO University of Applied Sciences Western Switzerland, 2000 Neuchâtel, Switzerland
2School of Life Sciences FHNW, Institute for Chemistry and Bioanalytics, Hofackerstrasse 30, 4132 Muttenz, Switzerland
3CSEM, Bahnhofstrasse 1, 7302 Landquart, Switzerland

Organs-on-Chips (OoCs) are microfluidics-based systems that aim to recapitulate the in-vivo behaviour of specific organs. Using a network of microfluidic channels, OoCs provide a biophysical and biochemical environment to sustain complex 2D and 3D cell cultures systems that recapitulate ... 詳細を見る

3-D Modeling of Light, Flow, Mass and Heat Transfer in Coral Colonies

Martinez Jimenez Fernan David1, Murthy Swathi2, Picioreanu Cristian1, Kühl Michael2
1King Abdullah University of Science and Technology (KAUST), Water Desalination and Reuse Center, Biological and Environmental Science and Engineering Division, Thuwal 23955-6900, Saudi Arabia
2Marine Biology Section, Department of Biology, University of Copenhagen, Strandpromenaden 5, 3000 Helsingør, Denmark

Corals are symbiotic marine organisms greatly dependent on the dynamic gradients of light, temperature and chemical species, all affected by the water flow in their surroundings. We developed a multiphysics modelling approach to simulate the microscale spatial distribution of light, ... 詳細を見る

Acoustic-Mechanic Modeling of Polydimethylsiloxane in the MHz Regime for Metamaterials Applications

Lucrezia Maini1, Prof. Christofer Hierold1, Dr. Cosmin Roman1
1Micro- and Nanosystems, ETH Zurich, 8092, Zurich, Switzerland

Polydimethylsiloxane (PDMS) is a biocompatible material widely used in biomedical applications such as implantable sensors. A realistic modeling of PDMS in acoustic-mechanic simulation is useful especially for medical applications which use ultrasonic waves as interrogation source. ... 詳細を見る

Numerical Simulation-Driven Design of Nanophotonic Biosensors

Duc Le1, Jussi Hiltunen1, Alexey Popov1
1VTT Technical Research Centre of Finland, 90590 Oulu, Finland

Optical biosensors are powerful analytical tools for detecting and quantifying biological molecules and particles with high sensitivity and specificity. These devices operate on the principle of detecting changes in optical signals. For example, surface plasmon resonance (SPR) biosensors ... 詳細を見る

Chemical Gradients, Carryover and Mixing in Fluidic Diagnostic Systems

Matthew Hancock1, Andrew Spann1, Andrew Fiore1
1Veryst Engineering, Needham, MA, United States

Recent events underscore the importance of rapid diagnostic tests for detecting viruses such as the SARS-CoV-2 coronavirus or for screening cancer biomarkers. Many fluidic-based diagnostics applications require careful control of chemical and biological species concentrations. In this ... 詳細を見る

Image based, geometry prescribed CFD of intra-cardiac flows on a dynamic heart phantom

Rasmus Hvid1, Marie Sand Traberg1
1Technical University of Denmark, department of health technology, Lyngby, Denmark

Introduction: The current gold standard for measuring intra-cardiac blood flow is cardiac magnetic resonance (CMR) and Color-Doppler ultrasound [ref1]. The presented simulation pipeline extracts heart wall motion from medical imaging and simulates the intra-cardiac blood flow as an ... 詳細を見る

FE-Simulation of PTCA Balloon Catheters

Cornelia Amstutz1, Roman Bühler1, Jean-Marc Behr2, Michael Stöver2, Adrian Zurbuchen1, Jürgen Burger2
1SITEM Center, University of Bern, Switzerland
2SIS Medical AG, Switzerland

Within 40 years, percutaneous transluminal coronary angioplasty (PTCA) catheters evolved into the golden standard for treating coronary stenoses. However, navigating through tortuous vessel pathways and cracking highly calcified lesions is challenging. To minimize the risk of ... 詳細を見る