Theoretical and Practical Approach for Transdermal Drug Delivery using Microneedle for Successful Skin Penetration
Jeevan J.Mahakud, Ziaur Reheman
Department of electronics and Communication engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
Department of electronics and instrumentation engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
With the advent of MEMS, transdermal drug delivery has been developed to increase skin permeability for drug transport. Various microneedle structures have been analyzed theoretically as well as through simulation using COMSOL Multiphysics®. Then computational fluid dynamics has been presented in order to study the behavior of the fluid flow inside the microneedle cavity. In this report, the ...
Modeling of Packed Bed Reactors: Hydrogen Production by the Steam Reforming of Methane and Glycerol - new
A. Dixon, B. MacDonald, A. Olm
Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA
The conventional route to hydrogen production is by steam reforming of methane (MSR) in a multitubular packed bed. With the increasing use of biodiesel as a renewable fuel, interest has grown in steam reforming of the excess glycerol produced as a side product (GSR). We use COMSOL Multiphysics® software to model a tubular packed bed reactor, solving a single pellet model at each point. The ...
B. Weber , D. Dauti , S. Dal Pont ,
 Empa, Swiss Federal Laboratories for Materials Science and Technology, Dübendorf, Switzerland
 Laboratoire 3SR, University Grenoble Alpes, Grenoble, France
When concrete is subjected to high temperature, capillary water evaporates and chemically bound water is released due to dehydration. This results in an increase of pore pressure, which is believed to be one of the mechanisms leading to spalling. Spalling of concrete is of high concern for the fire safety of concrete structures. We consider a model implemented in COMSOL® using the Weak Form ...
H. Zhu, T. Gulati, A. K. Datta, K. Huang
Institute of Applied Electromagnetics, Sichuan University, Chengdu, China
Department of Biological and Environment Engineering, Cornell University, Ithaca, NY, USA
Microwave drying of fruits and vegetables in a domestic oven has been found to result in large textural changes in the product such as puffing, crack formation and even burning due to the inhomogeneous heating of the microwaves. Microwave drying of potatoes is a complex interplay of mass, momentum and energy transport. Three phases are considered in the system: solid (skeleton), liquid (water) ...
A. Kermani , N. Elabbasi 
 Veryst Engineering, Needham, MA, USA
Transdermal drug delivery (TDD) is used to deliver drugs through the skin as an alternative to oral, intravascular, and subcutaneous routes. While there are many advantages to TDD, skin is a very effective barrier and provides resistance to drug delivery. To improve drug delivery through the skin, permeation enhancers are used. We developed an axisymmetric COMSOL Multiphysics® software model ...
H. Omar , S. Rohani ,
 University of Western Ontario, London, ON, Canada
The world’s landfills are beginning to fill up due to the growing human population. Landfills require land and there will come a time when there will be no land to be used for landfills. A solution that is gaining attraction is the conversion of traditional “dry-tomb” landfills (used for storage) into bioreactor landfills. Dry-tomb landfills have many associated problems such as methane ...
S. Cambon , I. Bogdanov 
Open & Experimental Center for Heavy Oil (CHLOE), University of Pau, Pau, France
The efficiency and environmental impact of oil production become a principal challenge of energy producing companies. The improvement of existing and development of novel methods are often feasible within either a “new” physical framework (from the viewpoint of oil reservoir applications) or a non-trivial combination of “known” phenomena. Last fifty years the dedicated reservoir simulators have ...
A. Warning , A. K. Datta ,
 Cornell University, Ithaca, NY, USA
The particle tracking model provided a deeper understanding to the experimental results. The model showed good agreement with experimental data for rotation, transport and attachment. In the attachment model, protrusions create low velocity, low shear regions increasing attachment while holes pull cells toward the surface and increase residence time on the surface increasing attachment rate.
O. Silva 
 Amphos 21 Consulting S.L. - iMaGe Consortium, Barcelona, Spain
Gas generation and transport through porous media is a process common to many field applications such as radioactive waste and underground gas storage. In these operations, the gas phase evolution depends on the thermodynamic conditions at depth, the properties of the fluids (density, viscosity, surface tension) and the geological formation (permeability, porosity, retention curve), as well as ...
Migration of Mineral Oil Saturated and Aromatic Hydrocarbons(MOSH, MOAH) through Multi-Layered Packaging into Food
C. Kirse , F. Edel , H. Briesen ,
 Chair of Process Systems Engineering, Technical University of Munich, Germany
Substances like Mineral Oil Saturated Hydrocarbons (MOSH) and Mineral Oil Aromatic Hydrocarbons (MOAH) are suspected to be carcinogenic. Furthermore, MOSH/MOAH migrate through the packaging into food stuff. This work aims at modelling, how much MOSH/MOAH migrates from the packaging into food to evaluate the exposure to toxic substances. The scope of the project is not to investigate one specific ...